Depression is a state of psyche characterized by a spectrum of negative feelings ranging from minor unhappiness to overwhelming despair. Though generally associated with emotional or psychological symptoms, depression can be accompanied by severe pain or other physical symptoms as well.

Millions of women, at some point in their lives, experience troublesome physical, emotional, and cognitive symptoms during the two weeks leading up to menstruation. When these symptoms interfere with day-to-day life, this is called premenstrual syndrome or PMS.